Dear CSSA members,

It is our great honor to announce that Dr. Hongbo Luo, associate professor of Pathology in Children’s Hospital has recently agreed to join the advisor board of HMS-CSSA (below is the bio-sketch of Dr. Luo). With his support, we believe HMS-CSSA will be able to serve our community better.

We are looking forward to working with him in the future.

Best

HMS-CSSA

Hongbo Luo, Ph.D.

Associate Professor of Pathology
Faculty, Ph.D. program in Biological and Biomedical Science
Faculty, Ph.D. program in Immunology
Harvard Medical School

Dr. Luo’s laboratory studies signal transduction pathways mediating a variety of neutrophil functions. The laboratory uses molecular, cellular, biochemical, and chemical genetic approaches as well as animal inflammation models to dissect these pathways. The ultimate goal is to develop more efficient and effective therapies to modulate neutrophil functions in various infectious and inflammatory diseases. His training and experience in molecular biology, cell biology, and immunology have prepared him to lead the proposed project. His graduate research was carried out in the lab of Melissa Moore, at the time an HHMI investigator at Brandeis University (recently moved to University of Massachusetts Medical School), where I studied molecular mechanisms of pre-mRNA splicing and received rigorous training in biochemistry and molecular biology. As a postdoctoral fellow with Solomon Snyder at Johns Hopkins University, He worked on an interesting family of signal molecules, inositol phosphates. His pioneering studies established a role for inositol phosphates in PtdIns(3,4,5)P3-meidated chemotactic signal transduction pathways and provide a novel mode of regulation for PtdIns(3,4,5) P3 signaling. The objective of the proposed research is to elucidate the role of reactive oxygen species (ROS)-induced actin glutathionylation in controlling actin dynamics in neutrophils. This research program stems from his recent finding that NADPH oxidase-dependent ROS act as key regulators of neutrophil chemotaxis. He hypothesized that ROS control actin dynamic in neutrophils via directly modulating actin glutathionylation. Relevant to this application he has established various assays to analyze neutrophil functions (e.g. time-lapse recording of migrating neutrophils, intravital microscopy to visualize neutrophil trafficking in vivo, neutrophil adoptive transfer, and detection of actin glutathionylation).