Dear HMS-CSSA members,

It is our great honor to announce that has recently agreed to join the advisor board of HMS-CSSA (below is the bio-sketch of Dr. Zhang). Dr. Zhang is the Fred Rosen Professor, Dept. of Genetics & Pediatrics, Harvard Medical School & Boston Children’s Hospital and an investigator of Howard Hughes Medical Institute. With his support, we believe HMS-CSSA will be able to serve our community better.

We are looking forward to working with him in the future.
Best
HMS-CSSA

Dr ZHANG’s shrot bio-sketch:

A.    Positions and Honors

Positions

07/12 – pre.       Fred Rosen Professor, Dept. of Genetics & Pediatrics, Harvard Medical School & Boston Children’s Hospital

09/05 – pre.       Investigator, Howard Hughes Medical Institute

05/09 – 06/12     Kenan Distinguished Professor, University of North Carolina at Chapel Hill

12/05 – 06/12     Professor, Dept. of Biochemistry & Biophysics, UNC at Chapel Hill

7/04 – 11/05      Associate Professor, Dept. of Biochemistry & Biophysics, UNC at Chapel Hill

8/99 – 6/04       Assistant Professor, Dept. of Biochemistry & Biophysics, UNC at Chapel Hill

Honors:

2012             Fred Rosen chair, Harvard Medical School & Boston Children’s Hospital

2009            Kenan Distinguished Professorship, University of North Carolina-Chapel Hill

2008           Top 10 authors of high-impact papers by ScienceWatch (http://scientific.thomson.com/press/2008/8438330/)

2005            Investigator, Howard Hughes Medical Institute

2004            Hettleman Prize for Artistic and Scholarly Achievement, UNC-Chapel Hill

2003            Gertrude B. Elion Cancer Research Award, AACR

B.    Representative Publications  (Selected out of 120 peer-reviewed publications).

1. Wang, H-B., Huang, Z.-Q., Li, X., Feng, Q., Erdjument-Bromage, H., Strahl, B.D., Briggs, S., Allis, D.C., Wong, J., Tempst, P., and Zhang, Y. (2001). Methylation of histone H4 at arginine 3 facilitates transcriptional activation by nuclear hormone receptor Science 293, 853-857.
2. Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R.S., Zhang, Y. (2002). Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298, 1039-1043.
3. Wang, H.-B., Wang, L., Erdjument-Bromage, H., Vidal, M., Tempst, P., Jones, R. S., and Zhang, Y. (2004) Role of H2A ubiquitination in Polycomb silencing. Nature 431, 873-878.
4. Okada, Y., Feng, Q., Lin, Y., Jiang, Q., Li, Y., Coffield, V. M., Su, L., Xu, G., and Zhang, Y. (2005). hDOT1L links histone methylation to leukemogenesis. Cell 121, 167-178.
5. Tsukada, Y., Fang, J., Erdjument-Bromage, H., Warren, M., Borchers, C., Tempst, P., and Zhang, Y. (2006). Histone demethylation by a family of JmjC domain-containing proteins. Nature 439, 811-816.
6. Okada, Y., Yamagata, K., Hong, K., Wakayama, T., and Zhang, Y. (2010). A role for the elongator complex in zygotic paternal genome demethylation. Nature 463, 554-558.
7. Ito, S., D’Alessioi, A.C., Taranova, O.V., Hong, K., Sowers, L.C., and Zhang, Y. (2010). Role of Tet proteins in 5mC to 5hmC conversion, ES cell self-renewal, and inner cell mass specification. Nature 466, 1129-1133.
8. Wu, H., D’Alessioi, A.C., Ito, S., Xia, K., Wang, Z., Cui, K., Zhao, K., Sun, Y., and Zhang, Y. (2011). Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature 473, 389-93.
9. Ito, S., Shen, L., Dai, Q., Wu, S.C., Collins, L.B., Swenberg, J.A., He, C., and Zhang, Y. (2011). Tet proteins can convert 5-methylcytosine to 5-formalcytosine and 5-carboxylcytosine. Science 333, 1300-03.
10. Inoue, A., and Zhang, Y. (2011). Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science 334, 194.
11. Liang, G., He, J., and Zhang, Y. (2012). Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming. Nature Cell Biol. 14, 457-466.